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Animal research studies have disclosed that the medicine passed rapidly across the placenta, accumulated uniquely in the melanin structures of the fetal eyes, as well as was retained in the eye tissues for 5 months after the drug had been done away with from the rest of the physical body.

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A handful of situations of retinal adjustments have been reported as taking place in people which got simply Plaquenil.

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The medication should be carried out with care in patients having G-6-PD (glucose-6-phosphate dehydrogenase) shortage.

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In its early kind, it shows up reversible on discontinuation of Plaquenil.